Gene
nthl1
- ID
- ZDB-GENE-120511-4
- Name
- nth-like DNA glycosylase 1
- Symbol
- nthl1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair. Predicted to act upstream of or within base-excision repair. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial adenomatous polyposis 3 | Alliance | Familial adenomatous polyposis 3 | 616415 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000445 | Helix-hairpin-helix motif |
| Conserved_site | IPR003651 | Endonuclease III-like, iron-sulphur cluster loop motif |
| Conserved_site | IPR004036 | Endonuclease III-like, conserved site-2 |
| Domain | IPR003265 | HhH-GPD domain |
| Family | IPR030841 | Endonuclease III-like protein 1 |
| Homologous_superfamily | IPR011257 | DNA glycosylase |
| Homologous_superfamily | IPR023170 | Helix-hairpin-helix, base-excision DNA repair, C-terminal |
Domain Details Per Protein
| Protein | Length | DNA glycosylase | Endonuclease III-like, conserved site-2 | Endonuclease III-like, iron-sulphur cluster loop motif | Endonuclease III-like protein 1 | Helix-hairpin-helix, base-excision DNA repair, C-terminal | Helix-hairpin-helix motif | HhH-GPD domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QBP9
|
430 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available