ZFIN is now using GRCz12tu for Genomic Data
Gene
thbs1a
- ID
- ZDB-GENE-120402-2
- Name
- thrombospondin 1a
- Symbol
- thbs1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in animal gross anatomical part developmental process; cell adhesion; and negative regulation of angiogenesis. Predicted to be located in cell surface; extracellular region; and sarcoplasmic reticulum. Predicted to be part of thrombospondin complex. Is expressed in atrioventricular canal and bulbus arteriosus. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Thrombospondin, C-terminal | Thrombospondin-like, N-terminal domain | Thrombospondin type-1 repeat superfamily | Thrombospondin type-1 (TSP1) repeat | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RI72 | InterPro | 965 | |||||||||||
| UniProtKB:A0AC58HQ14 | InterPro | 1173 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers