Gene
thbs1a
- ID
- ZDB-GENE-120402-2
- Name
- thrombospondin 1a
- Symbol
- thbs1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity; extracellular matrix binding activity; and heparin binding activity. Predicted to be involved in cell adhesion; inflammatory response; and negative regulation of angiogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).
- Genome Resources
-
- Alliance (1)
- Gene:100332237 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Abrial et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Length | Complement Clr-like EGF domain | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Thrombospondin, C-terminal | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RI72
|
965 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance