Gene

kcnj2a

ID
ZDB-GENE-120319-1
Name
potassium inwardly rectifying channel subfamily J member 2a
Symbol
kcnj2a Nomenclature History
Previous Names
  • kcnj2
  • Kir2.1 (1)
  • Kir2.1a (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to localize to plasma membrane. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnj2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Andersen-Tawil syndrome Alliance Andersen syndrome 170390
familial atrial fibrillation Alliance Atrial fibrillation, familial, 9 613980
short QT syndrome Alliance Short QT syndrome 3 609622
Associated With kcnj2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Domain IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
Domain IPR041647 Inward rectifier potassium channel, C-terminal
Family IPR003271 Potassium channel, inwardly rectifying, Kir2.1
Family IPR016449 Potassium channel, inwardly rectifying, Kir
Homologous_superfamily IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily IPR014756 Immunoglobulin E-set
Domain Details Per Protein
Protein Length Immunoglobulin E-set Inward rectifier potassium channel, C-terminal Potassium channel, inwardly rectifying, Kir Potassium channel, inwardly rectifying, Kir2.1 Potassium channel, inwardly rectifying, Kir, cytoplasmic Potassium channel, inwardly rectifying, Kir, N-terminal Potassium channel, inwardly rectifying, transmembrane domain
UniProtKB:E7FGH1 427
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations