Gene

pfkfb2b

ID
ZDB-GENE-120222-1
Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
Symbol
pfkfb2b Nomenclature History
Previous Names
  • fj21f03
  • wu:fj21f03
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa14301Allele with one point mutationUnknownSplice SiteENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa21882Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa41809Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With pfkfb2b Human Ortholog
No data available
Associated With pfkfb2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain IPR013079 6-phosphofructo-2-kinase
Family IPR003094 Fructose-2,6-bisphosphatase
Family IPR013078 Histidine phosphatase superfamily, clade-1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
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Domain Details Per Protein
Protein Length 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase Histidine phosphatase superfamily Histidine phosphatase superfamily, clade-1 Phosphoglycerate/bisphosphoglycerate mutase, active site P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QI21
InterPro
482
UniProtKB:A0A8M9QLY8
InterPro
539
UniProtKB:X1WEG8
InterPro
548
UniProtKB:A0A8M2B1V7
InterPro
559
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pfkfb2b-201 (1)
Ensembl
Ensembl 3,202 nt
ZFIN BLAST
mRNA pfkfb2b-202 (1)
Ensembl
Ensembl 537 nt
ZFIN BLAST
mRNA pfkfb2b-203 (1)
Ensembl
Ensembl 2,671 nt
ZFIN BLAST
mRNA pfkfb2b-204 (1)
Ensembl
Ensembl 1,617 nt
ZFIN BLAST
mRNA pfkfb2b-205 (1)
Ensembl
Ensembl 264 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-219E24ZFIN Curated Data
EncodesESTfj21f03
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_005155843 (1)3281 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CU207354 (1)141089 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A8M2B1V7 (1)559 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanPFKFB21
Amino acid sequence comparison (1)
MousePfkfb21
Amino acid sequence comparison (1)
Citations
TSV
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