Gene
nav1b
- ID
- ZDB-GENE-120215-84
- Name
- neuron navigator 1b
- Symbol
- nav1b Nomenclature History
- Previous Names
-
- si:ch1073-463c22.1
- zmp:0000000670 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be active in axon initial segment and microtubule cytoskeleton. Orthologous to human NAV1 (neuron navigator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8611 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa9298 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa10320 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10347 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44650 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa45268 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nav1b | Charlton-Perkins et al., 2019 | |
| CRISPR2-nav1b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | Nav/unc-53 family | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|
|
UniProtKB:A0A8M3B0T7
|
1479 | |||
|
UniProtKB:A0A8M6YZ18
|
1819 | |||
|
UniProtKB:A0A8M3ATQ4
|
1809 | |||
|
UniProtKB:A0A8M6YZ14
|
1824 | |||
|
UniProtKB:A0A8M6Z7K9
|
1805 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-181D11 | ZFIN Curated Data | |
| Contained in | BAC | CH73-334P16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-239B6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-463C22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068222072 (1) | 14456 nt | ||
| Genomic | GenBank:FP102924 (1) | 93168 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z1D6 (1) | 1825 aa |
- Comparative Orthology
- Alliance
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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