Gene
fmnl1a
- ID
- ZDB-GENE-120215-83
- Name
- formin-like 1a
- Symbol
- fmnl1a Nomenclature History
- Previous Names
-
- si:dkey-234e12.3
- unm_sa3326
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within actin cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in cytosol. Is expressed in several structures, including nervous system; notochord; optic cup; pharynx; and trunk. Orthologous to human FMNL1 (formin like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Santos-Ledo et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3326 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6040 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10153 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18761 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33252 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010472 | Formin, FH3 domain |
| Domain | IPR010473 | Formin, GTPase-binding domain |
| Domain | IPR014767 | Diaphanous autoregulatory (DAD) domain |
| Domain | IPR014768 | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
| Domain | IPR015425 | Formin, FH2 domain |
| Family | IPR043592 | Formin-like protein, animal |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR042201 | Formin, FH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Diaphanous autoregulatory (DAD) domain | Formin, FH2 domain | Formin, FH2 domain superfamily | Formin, FH3 domain | Formin, GTPase-binding domain | Formin-like protein, animal | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:I3ITQ8 | InterPro | 1085 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fmnl1a-201
(1)
|
Ensembl | 6,580 nt | ||
| mRNA |
fmnl1a-202
(1)
|
Ensembl | 4,067 nt | ||
| mRNA |
fmnl1a-203
(1)
|
Ensembl | 3,980 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234E12 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_680041 (1) | |||
| Genomic | GenBank:BX649535 (1) | 151079 nt | ||
| Polypeptide | UniProtKB:I3ITQ8 (1) | 1085 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gunning, P.W., Ghoshdastider, U., Whitaker, S., Popp, D., Robinson, R.C. (2015) The evolution of compositionally and functionally distinct actin filaments. Journal of Cell Science. 128:2009-19
- Santos-Ledo, A., Jenny, A., and Marlow, F.L. (2013) Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functions. Gene expression patterns : GEP. 13(1-2):30-37
1 - 5 of 5
Show