Gene

fmnl1a

ID

ZDB-GENE-120215-83

Name

formin-like 1a

Symbol

fmnl1a Nomenclature History

Previous Names

si:dkey-234e12.3
unm_sa3326

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within actin cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in cytosol. Is expressed in several structures, including nervous system; notochord; optic cup; pharynx; and trunk. Orthologous to human FMNL1 (formin like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Santos-Ledo et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fmnl1a Human Ortholog

No data available

Associated With fmnl1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010472	Formin, FH3 domain
Domain	IPR010473	Formin, GTPase-binding domain
Domain	IPR014767	Diaphanous autoregulatory (DAD) domain
Domain	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain	IPR015425	Formin, FH2 domain
Family	IPR043592	Formin-like protein, animal
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR042201	Formin, FH2 domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Diaphanous autoregulatory (DAD) domain	Formin, FH2 domain	Formin, FH2 domain superfamily	Formin, FH3 domain	Formin, GTPase-binding domain	Formin-like protein, animal	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:I3ITQ8 InterPro	1085

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fmnl1a-201 (1) Ensembl	Ensembl	6,580 nt	Select Tool ZFIN BLAST
mRNA	fmnl1a-202 (1) Ensembl	Ensembl	4,067 nt	Select Tool ZFIN BLAST
mRNA	fmnl1a-203 (1) Ensembl	Ensembl	3,980 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations