ZFIN is now using GRCz12tu for Genomic Data
Gene
kynu
- ID
- ZDB-GENE-120215-204
- Name
- kynureninase
- Symbol
- kynu Nomenclature History
- Previous Names
-
- si:ch73-379f7.2
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable kynureninase activity. Predicted to be involved in anthranilate metabolic process and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within NAD biosynthetic process and tryptophan catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hydroxykynureninuria | Alliance | ?Hydroxykynureninuria | 236800 |
| Vertebral, cardiac, renal, and limb defects syndrome 2 | 617661 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010111 | Kynureninase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Kynureninase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IQY2 | InterPro | 455 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers