Gene
mapkbp1
- ID
- ZDB-GENE-120207-1
- Name
- mitogen-activated protein kinase binding protein 1
- Symbol
- mapkbp1 Nomenclature History
- Previous Names
-
- si:dkey-89f23.3
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction and positive regulation of JNK cascade. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleus and spindle pole. Predicted to be active in cytoplasm. Is expressed in brain; head; and somite. Human ortholog(s) of this gene implicated in nephronophthisis 20. Orthologous to human MAPKBP1 (mitogen-activated protein kinase binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Macia et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephronophthisis 20 | Alliance | Nephronophthisis 20 | 617271 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR056161 | MABP1/WDR62, first WD40 domain |
| Domain | IPR056162 | MABP1/WDR62, second WD40 domain |
| Domain | IPR056364 | MABP1/WRD62, coiled-coil domain |
| Family | IPR055292 | Mitogen-activated protein kinase-binding protein 1 |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | MABP1/WDR62, first WD40 domain | MABP1/WDR62, second WD40 domain | MABP1/WRD62, coiled-coil domain | Mitogen-activated protein kinase-binding protein 1 | Quinoprotein alcohol dehydrogenase-like superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PL31 | InterPro | 1574 | ||||||||
| UniProtKB:A0A0R4ICM6 | InterPro | 1578 | ||||||||
| UniProtKB:A0A8M9P0C8 | InterPro | 1572 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapkbp1-201
(1)
|
Ensembl | 1,347 nt | ||
| mRNA |
mapkbp1-202
(1)
|
Ensembl | 5,155 nt | ||
| mRNA |
mapkbp1-203
(1)
|
Ensembl | 5,245 nt | ||
| mRNA |
mapkbp1-204
(1)
|
Ensembl | 5,263 nt |
Interactions and Pathways
No data available
Plasmids
No data available