Gene
kcnk17
- ID
- ZDB-GENE-120113-3
- Name
- potassium channel, subfamily K, member 17
- Symbol
- kcnk17 Nomenclature History
- Previous Names
-
- zmp:0000001165
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables open rectifier potassium channel activity. Acts upstream of or within potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to several human genes including KCNK17 (potassium two pore domain channel subfamily K member 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Staudacher et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14168 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Potassium channel domain | Two pore domain potassium channel |
|---|---|---|---|---|
| UniProtKB:A0A8M9PVM7 | InterPro | 299 | ||
| UniProtKB:A0A140LFQ8 | InterPro | 299 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk17-201
(1)
|
Ensembl | 1,423 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-264H24 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005158911 (1) | 1500 nt | ||
| Genomic | RefSeq:NW_018394999 (1) | |||
| Polypeptide | UniProtKB:A0A140LFQ8 (1) | 299 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Staudacher, I., Illg, C., Gierten, J., Seehausen, S., Schweizer, P.A., Katus, H.A., Thomas, D. (2018) Identification and functional characterization of zebrafish K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.. European Journal of Pharmacology. 831:94-102
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
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