Gene
prf1.1
- ID
- ZDB-GENE-111212-2
- Name
- perforin 1.1
- Symbol
- prf1.1 Nomenclature History
- Previous Names
-
- prf3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Predicted to be involved in cytolysis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Is expressed in gill; liver; muscle; and pleuroperitoneal region. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Varela et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FA66
|
580 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prf1.1-201
(1)
|
Ensembl | 2,175 nt |
Interactions and Pathways
No data available
Plasmids
No data available