Gene
prf1.8
- ID
- ZDB-GENE-111212-12
- Name
- perforin 1.8
- Symbol
- prf1.8 Nomenclature History
- Previous Names
-
- si:ch211-282e16.5
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR037300 | Perforin-1, C2 domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Family | IPR052784 | Perforin-1 pore-forming |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:I3ITP0
|
574 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bx547993.2-201
(1)
|
Ensembl | 1,908 nt |
Interactions and Pathways
No data available
Plasmids
No data available