Gene

prf1.7

ID
ZDB-GENE-111212-11
Name
perforin 1.7
Symbol
prf1.7 Nomenclature History
Previous Names
  • si:ch211-282e16.4
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable wide pore channel activity. Predicted to be involved in T cell mediated cytotoxicity; defense response to virus; and immunological synapse formation. Predicted to act upstream of or within immune response; killing of cells of another organism; and leukocyte mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa45671Allele with one point mutationUnknownUnknownENU
Zebrafish International Resource Center (ZIRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With prf1.7 Human Ortholog
No data available
Associated With prf1.7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR000008 C2 domain
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Domain IPR037300 Perforin-1, C2 domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length C2 domain C2 domain superfamily Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Perforin-1, C2 domain Perforin-1 pore-forming
UniProtKB:I3IS28 InterPro 574
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prf1 (1 of many)-201 (1)
Ensembl
Ensembl 1,898 nt
ZFIN BLAST
mRNA prf1.7-201 (1)
Ensembl
Ensembl 2,018 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-282E16ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_003200600 (1)1851 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:BX547993 (2)108908 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:I3IS28 (1)574 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
TSV
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Your Input Welcome
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