Gene

prf1.7

ID

ZDB-GENE-111212-11

Name

perforin 1.7

Symbol

prf1.7 Nomenclature History

Previous Names

si:ch211-282e16.4

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Predicted to be involved in cytolysis and immune response. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prf1.7 Human Ortholog

No data available

Associated With prf1.7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Domain	IPR000008	C2 domain
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Domain	IPR037300	Perforin-1, C2 domain
Family	IPR001862	Membrane attack complex component/perforin/complement C9
Family	IPR052784	Perforin-1 pore-forming
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	Membrane attack complex component/perforin/complement C9	Membrane attack complex component/perforin domain, conserved site	Membrane attack complex component/perforin (MACPF) domain	Perforin-1, C2 domain	Perforin-1 pore-forming
UniProtKB:I3IS28 InterPro	574

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prf1 (1 of many)-201 (1) Ensembl	Ensembl		1,898 nt	Select Tool ZFIN BLAST
mRNA	prf1.7-201 (1) Ensembl	Ensembl		2,018 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations