Gene
mars2
- ID
- ZDB-GENE-111201-1
- Name
- methionyl-tRNA synthetase 2, mitochondrial
- Symbol
- mars2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and methionine-tRNA ligase activity. Predicted to act upstream of or within methionyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 25 | Alliance | ?Combined oxidative phosphorylation deficiency 25 | 616430 |
| spastic ataxia 3 | Alliance | Spastic ataxia 3, autosomal recessive | 611390 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015413 | Methionyl/Leucyl tRNA synthetase |
| Domain | IPR033911 | Methioninyl-tRNA synthetase core domain |
| Domain | IPR041872 | Methionyl-tRNA synthetase, anticodon-binding domain |
| Family | IPR014758 | Methionyl-tRNA synthetase |
| Family | IPR023457 | Methionine-tRNA synthetase, type 2 |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Methionine-tRNA synthetase, type 2 | Methioninyl-tRNA synthetase core domain | Methionyl/Leucyl tRNA synthetase | Methionyl-tRNA synthetase | Methionyl-tRNA synthetase, anticodon-binding domain | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F5M3
|
595 |
Interactions and Pathways
No data available
Plasmids
No data available