ZFIN is now using GRCz12tu for Genomic Data
Gene
fat2
- ID
- ZDB-GENE-111031-1
- Name
- FAT atypical cadherin 2
- Symbol
- fat2 Nomenclature History
- Previous Names
-
- fk09f07
- wu:fk09f07
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion mediated by cadherin. Predicted to be located in membrane. Predicted to be active in adherens junction and plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2026
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia 45 | Alliance | Spinocerebellar ataxia 45 | 617769 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR056286 | CELSR1-3-like, ninth cadherin domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | CELSR1-3-like, ninth cadherin domain | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FB42 | InterPro | 4342 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance