Gene

lgr4

ID
ZDB-GENE-111013-1
Name
leucine-rich repeat containing G protein-coupled receptor 4
Symbol
lgr4 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable transmembrane signaling receptor activity. Involved in hypothalamus gonadotrophin-releasing hormone neuron development. Predicted to be located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; head; and pectoral fin bud. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Mancini et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
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Human Disease
Associated With lgr4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Delayed puberty, self-limited 619613
{Bone mineral density, low, susceptibility to} 615311
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Associated With lgr4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002131 Glycoprotein hormone receptor family
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
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Domain Details Per Protein
Protein Additional Resources Length Glycoprotein hormone receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype
UniProtKB:E7FE13 InterPro 971
UniProtKB:A0A8M9QHT5 InterPro 971
UniProtKB:A0AB13A784 InterPro 971
UniProtKB:A0AB32TYE2 InterPro 851
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lgr4-201 (1) Ensembl 6,857 nt
mRNA lgr4-202 (1) Ensembl 2,935 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-288G16
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLGR411
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseLgr42
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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