Gene
lgr4
- ID
- ZDB-GENE-111013-1
- Name
- leucine-rich repeat containing G protein-coupled receptor 4
- Symbol
- lgr4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane signaling receptor activity. Involved in hypothalamus gonadotrophin-releasing hormone neuron development. Predicted to be located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; head; and pectoral fin bud. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mancini et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lgr4 | Mancini et al., 2020 | |
| CRISPR2-lgr4 | Mancini et al., 2020 | |
| MO1-lgr4 | N/A | Guo et al., 2019 |
| MO2-lgr4 | N/A | Mancini et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR002131 | Glycoprotein hormone receptor family |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glycoprotein hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FE13 | InterPro | 971 | ||||||
| UniProtKB:A0A8M9QHT5 | InterPro | 971 | ||||||
| UniProtKB:A0AB13A784 | InterPro | 971 | ||||||
| UniProtKB:A0AB32TYE2 | InterPro | 851 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-288G16 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001353862 (1) | 6857 nt | ||
| Genomic | GenBank:BX511109 (2) | 124061 nt | ||
| Polypeptide | UniProtKB:A0A8M9QHT5 (1) | 971 aa |
- Square, T.A., Sundaram, S., Mackey, E.J., Miller, C.T. (2021) Distinct tooth regeneration systems deploy a conserved battery of genes. EvoDevo. 12:4
- Mancini, A., Howard, S.R., Marelli, F., Cabrera, C.P., Barnes, M.R., Sternberg, M.J., Leprovots, M., Hadjidemetriou, I., Monti, E., David, A., Wehkalampi, K., Oleari, R., Lettieri, A., Vezzoli, V., Vassart, G., Cariboni, A., Bonomi, M., Garcia, M.I., Guasti, L., Dunkel, L. (2020) LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling. JCI insight. 5(11):
- Guo, H., Du, X., Zhang, Y., Wu, J., Wang, C., Li, M., Hua, X., Zhang, X.A., Yan, J. (2019) Specific miRNA-GPCR networks regulate Sox9a/Sox9b activities to promote gonadal rejuvenation in zebrafish. Stem cells (Dayton, Ohio). 37(9):1189-1199
- Burrows, J.T., Pearson, B.J., Scott, I.C. (2015) An In Vivo Requirement for the Mediator Subunit Med14 in the Maintenance of Stem Cell Populations. Stem Cell Reports. 4(4):670-84
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hirose, K., Shimoda, N., and Kikuchi, Y. (2011) Expression patterns of lgr4 and lgr6 during zebrafish development. Gene expression patterns : GEP. 11(7):378-83
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