Gene
cyp27b1
- ID
- ZDB-GENE-111005-2
- Name
- cytochrome P450, family 27, subfamily B, polypeptide 1
- Symbol
- cyp27b1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Exhibits calcidiol 1-monooxygenase activity. Involved in hematopoietic stem cell proliferation. Human ortholog(s) of this gene implicated in obesity; rickets; and type 1 diabetes mellitus. Is expressed in heart; kidney; liver; and spleen. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1).
- Genome Resources
- Note
-
Based on ENSDART00000066178 in ZDB-PUB-110907-25.
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cortes et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vitamin D-dependent rickets type 1A | Alliance | Vitamin D-dependent rickets, type I | 264700 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, families 11 and 27 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A097HUX0
|
505 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp27b1-201
(1)
|
Ensembl | 2,142 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance