Gene

cyp27b1

ID
ZDB-GENE-111005-2
Name
cytochrome P450, family 27, subfamily B, polypeptide 1
Symbol
cyp27b1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Exhibits calcidiol 1-monooxygenase activity. Involved in hematopoietic stem cell proliferation. Is expressed in heart; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; and type 1 diabetes mellitus. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1).
Genome Resources
Note
Based on ENSDART00000066178 in ZDB-PUB-110907-25.
Comparative Information
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Cortes et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp27b1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vitamin D-dependent rickets type 1A Alliance Vitamin D-dependent rickets, type I 264700
Associated With cyp27b1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450 superfamily
UniProtKB:A0A140LGN8 506
UniProtKB:A0A097HUX0 505
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations