Gene
cxcl8b.3
- ID
- ZDB-GENE-111004-1
- Name
- chemokine (C-X-C motif) ligand 8b, duplicate 3
- Symbol
- cxcl8b.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Predicted to act upstream of or within chemotaxis; defense response; and immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including acute pyelonephritis; autoimmune uveitis; gastritis (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CXCL8 (C-X-C motif chemokine ligand 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC Chemokine domain |
|---|---|---|---|---|---|---|
| UniProtKB:A9ZPF0 | InterPro | 117 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl8b.3-201
(1)
|
Ensembl | 2,130 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115068 (1) | 415 nt | ||
| Genomic | GenBank:CABZ01030283 (1) | 46672 nt | ||
| Polypeptide | UniProtKB:A9ZPF0 (1) | 117 aa |
- Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:19501950
- Hu, F., Zhang, Y., Liu, Q., Wang, Z. (2022) PurA facilitates Edwardsiella piscicida to escape NF-κB signaling activation. Fish & shellfish immunology. 124:254-260
- Lin, C., Tang, Y., Wang, Y., Zhang, J., Li, Y., Xu, S., Xia, B., Zhai, Q., Li, Y., Zhang, L., Liu, J. (2022) WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish. Microbiology spectrum. 10(2):e0044321
- Blaser, B.W., Moore, J.L., Hagedorn, E.J., Li, B., Riquelme, R., Lichtig, A., Yang, S., Zhou, Y., Tamplin, O.J., Binder, V., Zon, L.I. (2017) CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. The Journal of experimental medicine. 214(4):1011
- Torraca, V., Cui, C., Boland, R., Bebelman, J.P., van der Sar, A.M., Smit, M.J., Siderius, M., Spaink, H.P., Meijer, A.H. (2015) The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease models & mechanisms. 8(3):253-69
- Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H.P., Schaaf, M.J., and Meijer, A.H. (2013) Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 190(4):1631-1645
- Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16
- Rotman, J., van Gils, W., Butler, D., Spaink, H.P., and Meijer, A.H. (2011) Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification. BMC research notes. 4(1):196
- van der Aa, L.M., Chadzinska, M., Tijhaar, E., Boudinot, P., and Verburg-van Kemenade, B.M. (2010) CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation. PLoS One. 5(8):e12384
- Nomiyama, H., Hieshima, K., Osada, N., Kato-Unoki, Y., Otsuka-Ono, K., Takegawa, S., Izawa, T., Yoshizawa, A., Kikuchi, Y., Tanase, S., Miura, R., Kusuda, J., Nakao, M., and Yoshie, O. (2008) Extensive Expansion and Diversification of the Chemokine Gene Family in Zebrafish: Identification of a Novel Chemokine Subfamily CX. BMC Genomics. 9(1):222
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