Gene
srr
- ID
- ZDB-GENE-110914-210
- Name
- serine racemase
- Symbol
- srr Nomenclature History
- Previous Names
-
- si:ch73-263o4.4
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable L-serine ammonia-lyase activity. Predicted to be involved in L-serine catabolic process. Predicted to act upstream of or within amino acid metabolic process. Orthologous to human SRR (serine racemase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-srr | Thyme et al., 2019 | |
| CRISPR2-srr | Thyme et al., 2019 | |
| CRISPR3-srr | Thyme et al., 2019 | |
| CRISPR4-srr | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000634 | Serine/threonine dehydratase, pyridoxal-phosphate-binding site |
| Domain | IPR001926 | Tryptophan synthase beta chain-like, PALP domain |
| Family | IPR050147 | Serine/Threonine Dehydratase |
| Homologous_superfamily | IPR036052 | Tryptophan synthase beta chain-like, PALP domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Serine/Threonine Dehydratase | Serine/threonine dehydratase, pyridoxal-phosphate-binding site | Tryptophan synthase beta chain-like, PALP domain | Tryptophan synthase beta chain-like, PALP domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:H0WEF6 | InterPro | 323 | ||||
| UniProtKB:A0AB32TTZ4 | InterPro | 316 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-263o4.4-201
(1)
|
Ensembl | 2,022 nt | ||
| mRNA |
si:ch73-263o4.4-202
(1)
|
Ensembl | 3,646 nt | ||
| mRNA |
si:ch73-263o4.4-203
(1)
|
Ensembl | 4,273 nt | ||
| mRNA |
si:ch73-263o4.4-204
(1)
|
Ensembl | 3,783 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-263O4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002661465 (1) | 1480 nt | ||
| Genomic | GenBank:CU855579 (1) | 75025 nt | ||
| Polypeptide | UniProtKB:H0WEF6 (1) | 323 aa |
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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