Gene

orai1a

ID
ZDB-GENE-110721-1
Name
ORAI calcium release-activated calcium modulator 1a
Symbol
orai1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to localize to membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Wasilewska et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With orai1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 9 Alliance Immunodeficiency 9 612782
tubular aggregate myopathy 2 Alliance Myopathy, tubular aggregate, 2 615883
Associated With orai1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR012446 Calcium release-activated calcium channel protein
Homologous_superfamily IPR038350 Orai superfamily
Domain Details Per Protein
Protein Length Calcium release-activated calcium channel protein Orai superfamily
UniProtKB:E7FFU7 188
UniProtKB:A0A0R4IYV8 225
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations