Gene

tshr

ID
ZDB-GENE-110524-4
Name
thyroid stimulating hormone receptor
Symbol
tshr Nomenclature History
Previous Names
  • manet (1)
  • opallus (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits thyroid-stimulating hormone receptor activity. Involved in skeletal system development. Predicted to localize to integral component of plasma membrane. Is expressed in thyroid follicle and thyroid primordium. Used to study hyperthyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tshr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nongoitrous hypothyroidism 1 Alliance Hypothyroidism, congenital, nongoitrous, 1 275200
hyperthyroidism Alliance Hyperthyroidism, familial gestational 603373
hyperthyroidism Alliance Hyperthyroidism, nonautoimmune 609152
Thyroid adenoma, hyperfunctioning, somatic
Thyroid carcinoma with thyrotoxicosis
Associated With tshr Via Experimental Models
Human Disease Fish Conditions Citations
hyperthyroidism tshrb1071/b1071 standard conditions Hur et al., 2017
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002131 Glycoprotein hormone receptor family
Family IPR002274 Thyrotropin receptor
Repeat IPR001611 Leucine-rich repeat
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Glycoprotein hormone receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Leucine-rich repeat Thyrotropin receptor
UniProtKB:F1Q981 757
UniProtKB:B0CLZ0 475
UniProtKB:C0SKM5 757
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations