Gene
hcn1
- ID
- ZDB-GENE-110520-1
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 1
- Symbol
- hcn1 Nomenclature History
- Previous Names
-
- hc5 (1)
- si:ch73-230k7.1
- zmp:0000000818
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated potassium channel activity. Acts upstream of or within neuron-neuron synaptic transmission and posterior lateral line neuromast hair cell development. Predicted to be part of HCN channel complex. Predicted to be active in axon and dendrite. Is expressed in neuromast hair cell.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 24 | Alliance | Developmental and epileptic encephalopathy 24 | 615871 |
| generalized epilepsy with febrile seizures plus 10 | Alliance | Generalized epilepsy with febrile seizures plus, type 10 | 618482 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG-like |
| Family | IPR051413 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium channel, voltage-dependent, EAG/ELK/ERG-like | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TAQ9 | InterPro | 925 | ||||||||
| UniProtKB:A0AB32TFK5 | InterPro | 671 | ||||||||
| UniProtKB:A0A0R4IRW0 | InterPro | 908 | ||||||||
| UniProtKB:A0A8M2BGT7 | InterPro | 654 | ||||||||
| UniProtKB:A0A8M9PIR0 | InterPro | 645 |
Interactions and Pathways
No data available
Plasmids
No data available