Gene
tpo
- ID
- ZDB-GENE-110519-2
- Name
- thyroid peroxidase
- Symbol
- tpo Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable peroxidase activity. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in extracellular space. Is expressed in thyroid follicle and thyroid primordium. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase).
- Genome Resources
-
- Alliance (1)
- Gene:569363 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Fang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 2A | Alliance | Thyroid dyshormonogenesis 2A | 274500 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital hypothyroidism | tpozf3605/zf3605 (TU) | standard conditions | Fang et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M9PP20
|
672 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance