Gene

grm8a

ID

ZDB-GENE-110421-2

Name

glutamate receptor, metabotropic 8a

Symbol

grm8a Nomenclature History

Previous Names

grm8b
mglur8a (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have group III metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Is expressed in brain and retinal neural layer. Orthologous to human GRM8 (glutamate metabotropic receptor 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Lüffe et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grm8a Human Ortholog

No data available

Associated With grm8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017979	GPCR, family 3, conserved site
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR011500	GPCR, family 3, nine cysteines domain
Domain	IPR017978	GPCR family 3, C-terminal
Family	IPR000162	GPCR, family 3, metabotropic glutamate receptor
Family	IPR000337	GPCR, family 3
Family	IPR001786	GPCR, family 3, metabotropic glutamate receptor 4
Family	IPR050726	Metabotropic Glutamate Receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR038550	GPCR, family 3, nine cysteines domain superfamily