Gene
cenpx
- ID
- ZDB-GENE-110411-78
- Name
- centromere protein X
- Symbol
- cenpx Nomenclature History
- Previous Names
-
- si:ch73-362i18.3
- stra13 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in replication fork processing and resolution of meiotic recombination intermediates. Predicted to act upstream of or within DNA repair and kinetochore assembly. Predicted to be located in nucleus. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Is expressed in liver and biliary system and pancreatic system. Orthologous to human CENPX (centromere protein X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cenpx | Zang et al., 2019 | |
| CRISPR2-cenpx | Zang et al., 2019 | |
| CRISPR3-cenpx | Zang et al., 2019 | |
| MO1-cenpx | N/A | Zang et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Centromere protein X | Histone-fold |
|---|---|---|---|---|
| UniProtKB:E7F1X6 | InterPro | 81 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-362I18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001303055 (1) | |||
| Genomic | GenBank:CU571328 (1) | 45077 nt | ||
| Polypeptide | UniProtKB:E7F1X6 (1) | 81 aa |
- Pan, Y.J., Tong, S.K., Hsu, C.W., Weng, J.H., Chung, B.C. (2022) Zebrafish Establish Female Germ Cell Identity by Advancing Cell Proliferation and Meiosis. Frontiers in cell and developmental biology. 10:866267
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Zang, L., Shimada, Y., Nakayama, H., Chen, W., Okamoto, A., Koide, H., Oku, N., Dewa, T., Shiota, M., Nishimura, N. (2019) Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Frontiers in genetics. 10:693
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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