Gene
mocs2
- ID
- ZDB-GENE-110411-53
- Name
- molybdenum cofactor synthesis 2
- Symbol
- mocs2 Nomenclature History
- Previous Names
-
- si:ch211-102e1.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable molybdopterin synthase activity and nucleotide binding activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of molybdopterin synthase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11072 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| molybdenum cofactor deficiency type B | Alliance | Molybdenum cofactor deficiency B | 252160 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR003448 | Molybdopterin biosynthesis MoaE |
| Family | IPR003749 | Sulfur carrier ThiS/MoaD-like |
| Family | IPR028887 | Molybdopterin synthase sulfur carrier subunit, eukaryote |
| Family | IPR028888 | Molybdopterin synthase catalytic subunit, eukaryotes |
| Family | IPR044672 | Molybdopterin synthase sulfur carrier subunit |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR016155 | Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp |
| Homologous_superfamily | IPR036563 | Molybdopterin biosynthesis MoaE subunit superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta-grasp domain superfamily | Molybdopterin biosynthesis MoaE | Molybdopterin biosynthesis MoaE subunit superfamily | Molybdopterin synthase catalytic subunit, eukaryotes | Molybdopterin synthase sulfur carrier subunit | Molybdopterin synthase sulfur carrier subunit, eukaryote | Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp | Sulfur carrier ThiS/MoaD-like |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z1C5 | InterPro | 159 | ||||||||
| UniProtKB:F8W2T9 | InterPro | 86 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:mocs2) |
|
| 1 | Karampelias et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-102E1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017358006 (1) | 968 nt | ||
| Genomic | GenBank:CU694950 (1) | 91561 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z1C5 (1) | 159 aa |
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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