Gene
tbx19
- ID
- ZDB-GENE-110411-5
- Name
- T-box transcription factor 19
- Symbol
- tbx19 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including heart morphogenesis; mesoderm formation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in diencephalon; pars anterior; and rostral pars anterior. Human ortholog(s) of this gene implicated in adrenocorticotropic hormone deficiency; alcohol dependence; and inherited metabolic disorder. Orthologous to human TBX19 (T-box transcription factor 19).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adrenocorticotropic hormone deficiency | Alliance | Adrenocorticotropic hormone deficiency | 201400 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Family | IPR002070 | Transcription factor, Brachyury |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, Brachyury | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RSL4 | InterPro | 436 | ||||||
| UniProtKB:A0A8M9Q8V0 | InterPro | 230 | ||||||
| UniProtKB:A0AB32TIU2 | InterPro | 436 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-155D24 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-70D5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003198759 (1) | 3480 nt | ||
| Genomic | RefSeq:NW_018395249 (1) | 630243 nt | ||
| Polypeptide | UniProtKB:A0A8M1RSL4 (1) | 436 aa |
- Fabian, P., Tseng, K.C., Smeeton, J., Lancman, J.J., Dong, P.D.S., Cerny, R., Crump, J.G. (2020) Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science (New York, N.Y.). 370:463-467
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- Graf, M., Teo Qi-Wen, E.R., Viktor Sarusie, M., Rajaei, F., Winkler, C. (2015) Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Molecular endocrinology (Baltimore, Md.). 29(2):187-99
- Tan, Y., Iimura, K., Sato, T., Ura, K., and Takagi, Y. (2013) Spatiotemporal expression of the dermatopontin gene in zebrafish Danio rerio. Gene. 516(2):277-284
- Ahn, D., You, K.H., and Kim, C.H. (2012) Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish. Mol. Biol. Evol.. 29(12):3959-3983
- Liu, N.A., Jiang, H., Ben-Shlomo, A., Wawrowsky, K., Fan, X.M., Lin, S., and Melmed, S. (2011) Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 108(20):8414-8419
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