Gene

itgb2

ID
ZDB-GENE-110411-4
Name
integrin, beta 2
Symbol
itgb2 Nomenclature History
Previous Names
  • si:dkey-260n18.4
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have amyloid-beta binding activity and integrin binding activity. Involved in definitive hemopoiesis. Predicted to localize to cell surface; focal adhesion; and integrin complex. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 5 from Xue et al., 2019
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Xue et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itgb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
leukocyte adhesion deficiency 1 Alliance Leukocyte adhesion deficiency 116920
Associated With itgb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002369 Integrin beta subunit, VWA domain
Domain IPR012896 Integrin beta subunit, tail
Domain IPR014836 Integrin beta subunit, cytoplasmic domain
Domain IPR016201 PSI domain
Domain IPR033760 Integrin beta N-terminal
Family IPR015439 Integrin beta-2 subunit
Family IPR015812 Integrin beta subunit
Homologous_superfamily IPR032695 Integrin domain superfamily
Homologous_superfamily IPR036349 Integrin beta tail domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Homologous_superfamily IPR037076 Integrin beta subunit, cytoplasmic domain superfamily
Domain Details Per Protein
Protein Length Integrin beta-2 subunit Integrin beta N-terminal Integrin beta subunit Integrin beta subunit, cytoplasmic domain Integrin beta subunit, cytoplasmic domain superfamily Integrin beta subunit, tail Integrin beta subunit, VWA domain Integrin beta tail domain superfamily Integrin domain superfamily PSI domain von Willebrand factor A-like domain superfamily
UniProtKB:E7FCN5 768
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations