Gene
ltc4s
- ID
- ZDB-GENE-110411-32
- Name
- leukotriene C4 synthase
- Symbol
- ltc4s Nomenclature History
- Previous Names
-
- si:dkey-33h4.2
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process. Predicted to localize to endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LTC4S (leukotriene C4 synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukotriene C4 synthase deficiency | 614037 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001129 | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein |
| Family | IPR001446 | 5-lipoxygenase-activating protein |
| Family | IPR050997 | Membrane-associated proteins in eicosanoid and glutathione metabolism |
| Homologous_superfamily | IPR023352 | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily |
Domain Details Per Protein
| Protein | Length | 5-lipoxygenase-activating protein | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Membrane-associated proteins in eicosanoid and glutathione metabolism |
|---|---|---|---|---|---|
|
UniProtKB:E7F8E5
|
153 |
Interactions and Pathways
No data available
Plasmids
No data available