Gene
hcn4l
- ID
- ZDB-GENE-110411-3
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 4l
- Symbol
- hcn4l Nomenclature History
- Previous Names
-
- hcn3 (1)
- si:dkeyp-74b4.2
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport; regulation of membrane depolarization; and sodium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport; sodium ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of HCN channel complex. Predicted to be active in axon and dendrite. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Fujii et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR051413 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TEJ3
|
1188 |
Interactions and Pathways
No data available
Plasmids
No data available