Gene
pthlhb
- ID
- ZDB-GENE-110411-206
- Name
- parathyroid hormone-like hormone b
- Symbol
- pthlhb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and peptide hormone receptor binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including head; mesenchymal cell; otic vesicle; pancreas; and thymus. Human ortholog(s) of this gene implicated in brachydactyly type E2. Orthologous to human PTHLH (parathyroid hormone like hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yan et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| brachydactyly type E2 | Alliance | Brachydactyly, type E2 | 613382 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Parathyroid hormone/parathyroid hormone-related protein | Parathyroid hormone-related protein |
|---|---|---|---|---|
| UniProtKB:Q1L5E7 | InterPro | 162 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pthlhb-201
(1)
|
Ensembl | 578 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-340G20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-112D9 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001043324 (1) | |||
| Genomic | GenBank:CU184832 (1) | 187294 nt | ||
| Polypeptide | UniProtKB:Q1L5E7 (1) | 162 aa |
- Hoyle, D.J., Dranow, D.B., Schilling, T.F. (2021) Pthlha and mechanical force control early patterning of growth zones in the zebrafish craniofacial skeleton. Development (Cambridge, England). 149(2):
- Anneser, L., Alcantara, I.C., Gemmer, A., Mirkes, K., Ryu, S., Schuman, E.M. (2020) The neuropeptide Pth2 dynamically senses others via mechanosensation. Nature. 588(7839):653-657
- McMillan, S.C., Zhang, J., Phan, H.E., Jeradi, S., Probst, L., Hammerschmidt, M., Akimenko, M.A. (2018) A regulatory pathway involving retinoic acid and calcineurin demarcates and maintains joint cells and osteoblasts in the fin regenerate. Development (Cambridge, England). 145(11)
- Suarez-Bregua, P., Cal, L., Cañestro, C., Rotllant, J. (2017) PTH Reloaded: A New Evolutionary Perspective. Frontiers in Physiology. 8:776
- Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
- Pinheiro, P. L., Cardoso, J.C., Power, D.M., Canário, A.V. (2012) Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evolutionary Biology. 12:110
- Yan, Y.L., Bhattacharya, P., He, X., Ponugoti, B., Marquardt, B., Layman, J., Grunloh, M., Postlethwait, J.H., and Rubin, D. (2012) Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. The Journal of endocrinology. 214(3):421-435
- Bhattacharya, P., Yan, Y.L., Postlethwait, J., and Rubin, D. (2011) Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. The Journal of endocrinology. 211(2):187-200
1 - 10 of 10
Show