Gene
bcl2b
- ID
- ZDB-GENE-110411-185
- Name
- BCL2 apoptosis regulator b
- Symbol
- bcl2b Nomenclature History
- Previous Names
-
- si:dkey-217f4.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia/lymphoma, B-cell, 2 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
| Conserved_site | IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site |
| Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
| Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
| Family | IPR002475 | Bcl2-like |
| Family | IPR013279 | Apoptosis regulator, Bcl-X |
| Family | IPR026298 | Bcl-2 family |
| Homologous_superfamily | IPR036834 | Bcl-2-like superfamily |
Domain Details Per Protein
| Protein | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W266
|
209 |
Interactions and Pathways
No data available
Plasmids
No data available