Gene

bcl2b

ID

ZDB-GENE-110411-185

Name

BCL2 apoptosis regulator b

Symbol

bcl2b Nomenclature History

Previous Names

si:dkey-217f4.3 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable channel activity. Predicted to be involved in apoptotic signaling pathway and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Leukemia/lymphoma, B-cell, 2

Associated With bcl2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR013279	Apoptosis regulator, Bcl-X
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily

Domain Details Per Protein

Protein	Length	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Apoptosis regulator, Bcl-2 protein, BH4	Apoptosis regulator, Bcl-X	Bcl-2, Bcl-2 homology region 1-3	Bcl-2 family	Bcl2-like	Bcl-2-like superfamily
UniProtKB:F8W266 InterPro	209

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	bcl2b-201 (1) Ensembl	Ensembl		4,017 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations