ZFIN is now using GRCz12tu for Genomic Data
Gene
sacs
- ID
- ZDB-GENE-110411-146
- Name
- sacsin molecular chaperone
- Symbol
- sacs Nomenclature History
- Previous Names
-
- si:ch73-346g24.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Hsp70 protein binding activity. Human ortholog(s) of this gene implicated in Charlevoix-Saguenay spastic ataxia. Orthologous to human SACS (sacsin molecular chaperone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charlevoix-Saguenay spastic ataxia | Alliance | Spastic ataxia, Charlevoix-Saguenay type | 270550 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Charlevoix-Saguenay spastic ataxia | sacsirc1/irc1 | standard conditions | Naef et al., 2025 |
| Charlevoix-Saguenay spastic ataxia | sacsirc1/irc1 | standard conditions | Naef et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000626 | Ubiquitin-like domain |
| Domain | IPR001623 | DnaJ domain |
| Domain | IPR007842 | HEPN domain |
| Family | IPR052972 | Sacsin chaperone regulator |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036869 | Chaperone J-domain superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Chaperone J-domain superfamily | DnaJ domain | HEPN domain | Histidine kinase/HSP90-like ATPase superfamily | Sacsin chaperone regulator | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3APK9 | InterPro | 4587 | |||||||
| UniProtKB:E7FCI9 | InterPro | 4578 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers