Gene

sacs

ID
ZDB-GENE-110411-146
Name
sacsin molecular chaperone
Symbol
sacs Nomenclature History
Previous Names
  • si:ch73-346g24.1 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Is predicted to enable Hsp70 protein binding activity and chaperone binding activity. Human ortholog(s) of this gene implicated in Charlevoix-Saguenay spastic ataxia. Orthologous to human SACS (sacsin molecular chaperone).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sacs Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charlevoix-Saguenay spastic ataxia Alliance Spastic ataxia, Charlevoix-Saguenay type 270550
Associated With sacs Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000626 Ubiquitin-like domain
Domain IPR001623 DnaJ domain
Domain IPR007842 HEPN domain
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036869 Chaperone J-domain superfamily
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Domain Details Per Protein
Protein Length Chaperone J-domain superfamily DnaJ domain HEPN domain Histidine kinase/HSP90-like ATPase superfamily Ubiquitin-like domain Ubiquitin-like domain superfamily
UniProtKB:A0A2R8Q3T2 4512
UniProtKB:E7FCI9 4578
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations