Gene
agtr1b
- ID
- ZDB-GENE-110411-117
- Name
- angiotensin II receptor, type 1b
- Symbol
- agtr1b Nomenclature History
- Previous Names
-
- si:dkey-65o9.2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable angiotensin type I receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential} | 145500 |
| Renal tubular dysgenesis | 267430 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Angiotensin II receptor family | Angiotensin II receptor type 1 | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FEQ8
|
359 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
agtr1b-201
(1)
|
Ensembl | 1,080 nt | ||
| mRNA |
agtr1b-202
(1)
|
Ensembl | 1,393 nt |
Interactions and Pathways
No data available
Plasmids
No data available