slc25a22a

ID

ZDB-GENE-110408-61

Name

solute carrier family 25 member 22a

Symbol

slc25a22a Nomenclature History

Previous Names

si:dkey-201c1.2

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. Is expressed in brain; intestine; and swim bladder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A22 (solute carrier family 25 member 22).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lee et al., 2025

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Lee et al., 2025
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc25a22a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 3	Alliance	Developmental and epileptic encephalopathy 3	609304

Associated With slc25a22a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002067	Mitochondrial carrier protein
Family	IPR051028	Mitochondrial Solute Carrier
Homologous_superfamily	IPR023395	Mitochondrial carrier domain superfamily
Repeat	IPR018108	Mitochondrial substrate/solute carrier