Gene
tubb1
- ID
- ZDB-GENE-110408-5
- Name
- tubulin, beta 1 class VI
- Symbol
- tubb1 Nomenclature History
- Previous Names
-
- si:ch211-122i22.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in autosomal dominant macrothrombocytopenia TUBB1-related. Orthologous to human TUBB1 (tubulin beta 1 class VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant isolated macrothrombocytopenia 1 | Alliance | Macrothrombocytopenia, isolated, 1, autosomal dominant | 613112 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR013838 | Beta tubulin, autoregulation binding site |
Conserved_site | IPR017975 | Tubulin, conserved site |
Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
Family | IPR000217 | Tubulin |
Family | IPR002453 | Beta tubulin |
Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
Protein | Length | Beta tubulin | Beta tubulin, autoregulation binding site | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7FC32
|
466 |
Interactions and Pathways
No data available
Plasmids
No data available