Gene
tubb1
- ID
- ZDB-GENE-110408-5
- Name
- tubulin, beta 1 class VI
- Symbol
- tubb1 Nomenclature History
- Previous Names
-
- si:ch211-122i22.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in autosomal dominant macrothrombocytopenia TUBB1-related. Orthologous to human TUBB1 (tubulin beta 1 class VI).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant macrothrombocytopenia TUBB1-related | Alliance | Macrothrombocytopenia, isolated, 1, autosomal dominant | 613112 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR013838 | Beta tubulin, autoregulation binding site |
Conserved_site | IPR017975 | Tubulin, conserved site |
Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
Family | IPR000217 | Tubulin |
Family | IPR002453 | Beta tubulin |
Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
Protein | Length | Beta tubulin | Beta tubulin, autoregulation binding site | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7FC32
|
466 |
Interactions and Pathways
No data available
Plasmids
No data available