Gene

tubb1

ID
ZDB-GENE-110408-5
Name
tubulin, beta 1 class VI
Symbol
tubb1 Nomenclature History
Previous Names
  • si:ch211-122i22.4
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in autosomal dominant macrothrombocytopenia TUBB1-related. Orthologous to human TUBB1 (tubulin beta 1 class VI).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tubb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant macrothrombocytopenia TUBB1-related Alliance Macrothrombocytopenia, isolated, 1, autosomal dominant 613112
Associated With tubb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR013838 Beta tubulin, autoregulation binding site
Conserved_site IPR017975 Tubulin, conserved site
Domain IPR003008 Tubulin/FtsZ, GTPase domain
Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
Family IPR000217 Tubulin
Family IPR002453 Beta tubulin
Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
Homologous_superfamily IPR023123 Tubulin, C-terminal
Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily IPR037103 Tubulin/FtsZ-like, C-terminal domain
Domain Details Per Protein
Protein Length Beta tubulin Beta tubulin, autoregulation binding site Tubulin Tubulin, conserved site Tubulin, C-terminal Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ, C-terminal Tubulin/FtsZ, GTPase domain Tubulin/FtsZ, GTPase domain superfamily Tubulin/FtsZ-like, C-terminal domain
UniProtKB:E7FC32 466
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA tubb1-201 (1) Havana 1473 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations