Gene
slc6a2
- ID
- ZDB-GENE-110408-4
- Name
- solute carrier family 6 member 2
- Symbol
- slc6a2 Nomenclature History
- Previous Names
-
- si:dkey-182h7.3
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable dopamine:sodium symporter activity and norepinephrine:sodium symporter activity. Predicted to be involved in amino acid transport; catecholamine transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in axon; neuronal cell body membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Puttonen et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cf5Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| cf6Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| cf7Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa13869 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21005 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| postural orthostatic tachycardia syndrome | Alliance | ?Orthostatic intolerance | 604715 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|---|
| UniProtKB:F1R3H6 | InterPro | 625 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a2-201
(1)
|
Ensembl | 5,388 nt | ||
| mRNA |
slc6a2-202
(1)
|
Ensembl | 5,367 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-182H7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_689046 (1) | 2605 nt | ||
| Genomic | GenBank:BX663609 (1) | 248960 nt | ||
| Polypeptide | UniProtKB:F1R3H6 (1) | 625 aa |
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Zhao, G., Hu, J., Gao, M., Zhu, Y., Hong, Y. (2022) Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Ecotoxicology and environmental safety. 238:113611
- Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Mu, Y., Bennett, D.V., Rubinov, M., Narayan, S., Yang, C.T., Tanimoto, M., Mensh, B.D., Looger, L.L., Ahrens, M.B. (2019) Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior. Cell. 178(1):27-43.e19
- Tang, Y.Q., Li, Z.R., Zhang, S.Z., Mi, P., Chen, D.Y., Feng, X.Z. (2019) Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. Neurotoxicology and teratology. 76:106835
- Farrar, M.J., Kolkman, K.E., Fetcho, J.R. (2018) Features of the structure, development and activity of the Zebrafish Noradrenergic System explored in new CRISPR transgenic lines. The Journal of comparative neurology. 526(15):2493-2508
- Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2017) Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. 191:954-961
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