Gene

slc6a2

ID
ZDB-GENE-110408-4
Name
solute carrier family 6 member 2
Symbol
slc6a2 Nomenclature History
Previous Names
  • si:dkey-182h7.3
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable dopamine:sodium symporter activity and norepinephrine:sodium symporter activity. Predicted to be involved in dopamine uptake involved in synaptic transmission; norepinephrine transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection; neuronal cell body membrane; and presynaptic membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hypertension and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Puttonen et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc6a2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
postural orthostatic tachycardia syndrome Alliance ?Orthostatic intolerance 604715
Associated With slc6a2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000175 Sodium:neurotransmitter symporter
Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
Domain Details Per Protein
Protein Length Sodium:neurotransmitter symporter Sodium:neurotransmitter symporter superfamily
UniProtKB:F1R3H6 625
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations