Gene
rxfp2b
- ID
- ZDB-GENE-110408-27
- Name
- relaxin family peptide receptor 2b
- Symbol
- rxfp2b Nomenclature History
- Previous Names
-
- rxfp2a
- si:dkey-1o1.1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism; male organism; ovary; and testis. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2).
- Genome Resources
- Note
-
In March of 2012 this gene was found to be orthologous (both AA and synteny) to human and mouse RXFP2. The curator named this gene rxfp2a, in accordance with Zebrafish Nomenclature Guidelines. In the same month, Yegorov and Good (2012) named this gene rxpfb. Subsequently, two additional publications have maintained Yegorov and Good's nomenclature. In November of 2015 the names and gene symbols of both paralogs were changed to reflect a request filed with NCBI that was forwarded to the ZFIN nomenclature coordinator.
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28490 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa28491 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa35927 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42578 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR008112 | Relaxin receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
1 - 5 of 9 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | LDL receptor-like superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Relaxin receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F8W5N7 | InterPro | 750 | |||||||||
| UniProtKB:A0AB32T549 | InterPro | 615 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rxfp2b-204
(1)
|
Ensembl | 2,523 nt | ||
| mRNA |
rxfp2b-203
(1)
|
Ensembl | 2,510 nt | ||
| mRNA |
rxfp2b-205
(1)
|
Ensembl | 1,443 nt | ||
| ncRNA |
rxfp2b-003
(1)
|
Ensembl | 516 nt | ||
| ncRNA |
rxfp2b-004
(1)
|
Ensembl | 436 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(rxfp2b:mCherry) |
|
| 1 | Crespo et al., 2021 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1O1 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328082 (1) | |||
| Genomic | GenBank:CR536612 (1) | 224998 nt | ||
| Polypeptide | UniProtKB:F8W5N7 (1) | 750 aa |
- Donizetti, A., Calicchio, M., Romano, M.Z., Rosati, L., Turco, M., Carrese, A.M., Del Gaudio, R., Ferrandino, I., Aniello, F. (2024) Expression of Insl3 Protein in Adult Danio rerio. International Journal of Molecular Sciences. 25(10):
- Crespo, D., Assis, L.H.C., Zhang, Y.T., Safian, D., Furmanek, T., Skaftnesmo, K.O., Norberg, B., Ge, W., Choi, Y.C., den Broeder, M.J., Legler, J., Bogerd, J., Schulz, R.W. (2021) Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. Communications biology. 4:204
- Alnafea, H., Vahkal, B., Zelmer, C.K., Yegorov, S., Bogerd, J., Good, S.V. (2019) Japanese medaka as a model for studying the relaxin family genes involved in neuroendocrine regulation: Insights from the expression of fish-specific rln3 and insl5 and rxfp3/4-type receptor paralogues. Molecular and Cellular Endocrinology. 487:2-11
- de Castro Assis, L.H., Nobrega, R.H., Gómez-González, N.E., Bogerd, J., Schulz, R. (2018) Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen. Journal of molecular endocrinology. 60(4):273-284
- Gao, S., Liu, S., Yao, J., Li, N., Yuan, Z., Zhou, T., Li, Q., Liu, Z. (2017) Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Biochimica et biophysica acta. 1861(3):644-651
- Weh, E., Takeuchi, H., Muheisen, S., Haltiwanger, R.S., Semina, E.V. (2017) Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. PLoS One. 12:e0184903
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Donizetti, A., Fiengo, M., Del Gaudio, R., Iazzetti, G., Pariante, P., Minucci, S., Aniello, F. (2015) Expression pattern of zebrafish rxfp2 homologue genes during embryonic development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 324(7):605-13
- Good, S., Yegorov, S., Martijn, J., Franck, J., and Bogerd, J. (2012) New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. International Journal of Evolutionary Biology. 2012:310278
1 - 9 of 9
Show