Gene
jupb
- ID
- ZDB-GENE-110407-10
- Name
- junction plakoglobin b
- Symbol
- jupb Nomenclature History
- Previous Names
-
- si:ch73-362f1.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to adherens junction and catenin complex. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| arrhythmogenic right ventricular dysplasia 12 | Alliance | ?Arrhythmogenic right ventricular dysplasia 12 | 611528 |
| Naxos disease | Alliance | Naxos disease | 601214 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Beta-catenin |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PS81
|
722 |
Interactions and Pathways
No data available
Plasmids
No data available