Gene
man2a2
- ID
- ZDB-GENE-110331-1
- Name
- mannosidase, alpha, class 2A, member 2
- Symbol
- man2a2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose metabolic process; and protein deglycosylation. Predicted to localize to Golgi membrane. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
a298 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
sa3293 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa7259 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa13130 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa24615 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39473 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa44244 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-man2a2 | Thyme et al., 2019 | |
CRISPR2-man2a2 | Thyme et al., 2019 | |
CRISPR3-man2a2 | Thyme et al., 2019 | |
CRISPR4-man2a2 | Thyme et al., 2019 |
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Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
schizophrenia | man2a2a298/a298 | standard conditions | Thyme et al., 2019 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000602 | Glycoside hydrolase family 38, N-terminal domain |
Domain | IPR011682 | Glycosyl hydrolase family 38, C-terminal |
Domain | IPR015341 | Glycoside hydrolase family 38, central domain |
Family | IPR050843 | Glycosyl Hydrolase Family 38 |
Homologous_superfamily | IPR011013 | Galactose mutarotase-like domain superfamily |
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Domain Details Per Protein
Protein | Length | Galactose mutarotase-like domain superfamily | Glycoside hydrolase 38, N-terminal domain superfamily | Glycoside hydrolase/deacetylase, beta/alpha-barrel | Glycoside hydrolase families 57/38, central domain superfamily | Glycoside hydrolase family 38, central domain | Glycoside hydrolase family 38, central domain superfamily | Glycoside hydrolase family 38, N-terminal domain | Glycosyl hydrolase, all-beta | Glycosyl Hydrolase Family 38 | Glycosyl hydrolase family 38, C-terminal |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7EYL2
|
1151 | ||||||||||
UniProtKB:A0A8M3B6Z4
|
1167 | ||||||||||
UniProtKB:A0A8M3AWC8
|
1174 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
man2a2-201
(1)
|
Ensembl | 7,815 nt | ||
mRNA |
man2a2-202
(1)
|
Ensembl | 4,228 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-107J19 | ZFIN Curated Data | |
Contained in | BAC | CH211-256J21 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-517O12 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009297801 (1) | 7818 nt | ||
Genomic | GenBank:CR407564 (2) | 180337 nt | ||
Polypeptide | UniProtKB:A0A8M3AWC8 (1) | 1174 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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