Gene

man2a2

ID
ZDB-GENE-110331-1
Name
mannosidase, alpha, class 2A, member 2
Symbol
man2a2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose metabolic process; and protein deglycosylation. Predicted to localize to Golgi membrane. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a298Allele with multiple variantsUnknownUnknownCRISPR
sa3293Allele with one point mutationUnknownPremature StopENU
sa7259Allele with one point mutationUnknownSplice SiteENU
sa13130Allele with one point mutationUnknownSplice SiteENU
sa24615Allele with one point mutationUnknownPremature StopENU
sa39473Allele with one point mutationUnknownSplice SiteENU
sa44244Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With man2a2 Human Ortholog
No data available
Associated With man2a2 Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia man2a2a298/a298 standard conditions Thyme et al., 2019
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000602 Glycoside hydrolase family 38, N-terminal domain
Domain IPR011682 Glycosyl hydrolase family 38, C-terminal
Domain IPR015341 Glycoside hydrolase family 38, central domain
Family IPR050843 Glycosyl Hydrolase Family 38
Homologous_superfamily IPR011013 Galactose mutarotase-like domain superfamily
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Domain Details Per Protein
Protein Length Galactose mutarotase-like domain superfamily Glycoside hydrolase 38, N-terminal domain superfamily Glycoside hydrolase/deacetylase, beta/alpha-barrel Glycoside hydrolase families 57/38, central domain superfamily Glycoside hydrolase family 38, central domain Glycoside hydrolase family 38, central domain superfamily Glycoside hydrolase family 38, N-terminal domain Glycosyl hydrolase, all-beta Glycosyl Hydrolase Family 38 Glycosyl hydrolase family 38, C-terminal
UniProtKB:E7EYL2 1151
UniProtKB:A0A8M3B6Z4 1167
UniProtKB:A0A8M3AWC8 1174
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA man2a2-201 (1) Ensembl 7,815 nt
mRNA man2a2-202 (1) Ensembl 4,228 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-107J19ZFIN Curated Data
Contained inBACCH211-256J21ZFIN Curated Data
Contained inFosmidCH1073-517O12ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMAN2A215
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseMan2a27
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations