Gene

smc6

ID
ZDB-GENE-110303-1
Name
structural maintenance of chromosomes 6
Symbol
smc6 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within double-strand break repair. Predicted to be located in chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in head and post-vent region. Orthologous to human SMC6 (structural maintenance of chromosomes 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Li et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa36304Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa36305Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa36306Allele with one point mutationUnknownSplice SiteENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With smc6 Human Ortholog
No data available
Associated With smc6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003395 RecF/RecN/SMC, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
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Domain Details Per Protein
Protein Additional Resources Length P-loop containing nucleoside triphosphate hydrolase RecF/RecN/SMC, N-terminal
UniProtKB:A0A8M9Q634 InterPro 1097
UniProtKB:A0A8M2B5G4 InterPro 1094
UniProtKB:X1WGQ9 InterPro 1093
UniProtKB:A0A8M9Q235 InterPro 678
UniProtKB:A0A8M6YTX5 InterPro 674
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Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA smc6-201 (1)
Ensembl
Ensembl 3,742 nt
ZFIN BLAST
mRNA smc6-203 (1)
Ensembl
Ensembl 3,592 nt
ZFIN BLAST
mRNA smc6-204 (1)
Ensembl
Ensembl 3,829 nt
ZFIN BLAST
ncRNA smc6-002 (1)
Ensembl
Ensembl 505 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-189E2ZFIN Curated Data
Contained inBACCH211-191L23ZFIN Curated Data
Contained inBACDKEY-37O3ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_021473054 (1)3729 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:AL929338 (1)179399 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A8M9PV42 (1)1098 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSMC62
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseSmc612
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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