ZFIN is now using GRCz12tu for Genomic Data
Gene
adamts3
- ID
- ZDB-GENE-110223-1
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 3
- Symbol
- adamts3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within protein processing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; nervous system; otic vesicle; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Jayadev et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hennekam lymphangiectasia-lymphedema syndrome 3 | 618154 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PJM4 | InterPro | 1192 | |||||||||||
| UniProtKB:S5RVW8 | InterPro | 1164 | |||||||||||
| UniProtKB:A0A8M6Z0H1 | InterPro | 802 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts3-201
(1)
|
Ensembl | 3,778 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance