Gene
kl
- ID
- ZDB-GENE-110221-1
- Name
- klotho
- Symbol
- kl Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have beta-glucosidase activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to localize to endoplasmic reticulum. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Tumoral calcinosis, hyperphosphatemic, familial, 3 | 617994 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycoside hydrolase family 1 | Glycoside hydrolase superfamily |
|---|---|---|---|
|
UniProtKB:F1RC43
|
990 | ||
|
UniProtKB:A0A8N7TDV5
|
990 |
Interactions and Pathways
No data available
Plasmids
No data available