Gene

kl

ID
ZDB-GENE-110221-1
Name
klotho
Symbol
kl Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have beta-glucosidase activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to localize to endoplasmic reticulum. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Tumoral calcinosis, hyperphosphatemic, familial, 3 617994
Associated With kl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001360 Glycoside hydrolase family 1
Homologous_superfamily IPR017853 Glycoside hydrolase superfamily
Domain Details Per Protein
Protein Length Glycoside hydrolase family 1 Glycoside hydrolase superfamily
UniProtKB:F1RC43 990
UniProtKB:A0A8N7TDV5 990
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA kl-201 (1) Ensembl 7,449 nt
mRNA kl-202 (1) Ensembl 3,591 nt
mRNA kl-203 (1) Ensembl 7,341 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations