ZFIN is now using GRCz12tu for Genomic Data
Gene
ghrhrb
- ID
- ZDB-GENE-110127-2
- Name
- growth hormone releasing hormone receptor b
- Symbol
- ghrhrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable vasoactive intestinal polypeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in bone disease; isolated growth hormone deficiency; and isolated growth hormone deficiency type IB. Orthologous to human GHRHR (growth hormone releasing hormone receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated growth hormone deficiency type IB | Alliance | Growth hormone deficiency, isolated, type IV | 618157 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR001771 | GPCR, family 2, vasoactive intestinal peptide receptor 1 |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPCR, family 2, vasoactive intestinal peptide receptor 1 | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q130 | InterPro | 529 | |||||||
| UniProtKB:E7FF79 | InterPro | 453 | |||||||
| UniProtKB:A0AB32TTN3 | InterPro | 568 | |||||||
| UniProtKB:A0AC58JVD5 | InterPro | 398 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ghrhrb-201
(1)
|
Ensembl | 2,172 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance