Gene

mical2a

ID

ZDB-GENE-110110-2

Name

microtubule associated monooxygenase, calponin and LIM domain containing 2a

Symbol

mical2a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have several functions, including FAD binding activity; NADPH:sulfur oxidoreductase activity; and actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to localize to filamentous actin and microtubule organizing center. Is expressed in fin; heart; heart tube; and pharyngeal arch. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Xue et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mical2a Human Ortholog

No data available

Associated With mical2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001715	Calponin homology domain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR002938	FAD-binding domain
Family	IPR050540	F-actin Monooxygenase Mical
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calponin homology domain	CH domain superfamily	F-actin Monooxygenase Mical	FAD-binding domain	FAD/NAD(P)-binding domain superfamily	Zinc finger, LIM-type
UniProtKB:A0A8M9Q2X0 InterPro	1201
UniProtKB:A0A8M9PQ90 InterPro	1292
UniProtKB:A0A8M3AUM7 InterPro	1158
UniProtKB:A0A8M9Q915 InterPro	1132
UniProtKB:A0A8M9QD58 InterPro	979
UniProtKB:A0A8M9QI47 InterPro	1053
UniProtKB:A0A8M9PQ94 InterPro	944

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mical2a-201 (1) Ensembl	Ensembl	3,980 nt	Select Tool ZFIN BLAST
mRNA	mical2a-202 (1) Ensembl	Ensembl	2,505 nt	Select Tool ZFIN BLAST
mRNA	mical2a-203 (1) Ensembl	Ensembl	1,896 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations