Gene

kcnma1b

ID
ZDB-GENE-101209-2
Name
potassium large conductance calcium-activated channel, subfamily M, alpha member 1b
Symbol
kcnma1b Nomenclature History
Previous Names
  • slo1b (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Is predicted to enable large conductance calcium-activated potassium channel activity. Acts upstream of or within response to auditory stimulus. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Rohmann et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnma1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cerebellar atrophy, developmental delay, and seizures 617643
Liang-Wang syndrome 618729
Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy 609446
{Epilepsy, idiopathic generalized, susceptibility to, 16} 618596
Associated With kcnma1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003148 Regulator of K+ conductance, N-terminal
Domain IPR013099 Potassium channel domain
Family IPR024939 Calcium-activated potassium channel Slo-1
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Calcium-activated potassium channel Slo-1 NAD(P)-binding domain superfamily Potassium channel domain Regulator of K+ conductance, N-terminal
UniProtKB:B7TLZ1 206
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations