Gene
mtrr
- ID
- ZDB-GENE-101115-3
- Name
- 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- Symbol
- mtrr Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have coenzyme binding activity and oxidoreductase activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to localize to cytosol. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and ulcerative colitis. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Burkhalter et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Burkhalter et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| homocystinuria-megaloblastic anemia cblE type | Alliance | Homocystinuria-megaloblastic anemia, cbl E type | 236270 |
| neural tube defect | Alliance | {Neural tube defects, folate-sensitive, susceptibility to} | 601634 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| visceral heterotaxy | WT + MO1-mtrr | standard conditions | Burkhalter et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR008254 | Flavodoxin/nitric oxide synthase |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR023173 | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily |
| Homologous_superfamily | IPR029039 | Flavoprotein-like superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IZR6
|
695 | ||||||||||
|
UniProtKB:F1RE28
|
697 | ||||||||||
|
UniProtKB:A0A8M2B9H1
|
696 |
Interactions and Pathways
No data available
Plasmids
No data available