Gene
megf6b
- ID
- ZDB-GENE-101112-3
- Name
- multiple EGF-like-domains 6b
- Symbol
- megf6b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and scavenger receptor activity. Acts upstream of or within caudal fin morphogenesis and ossification involved in bone maturation. Is expressed in apical ectodermal ridge pectoral fin bud; head; mouth; and notochord. Orthologous to human MEGF6 (multiple EGF like domains 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Teerlink et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Teerlink et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mn0325Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2600 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9346 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9355 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15275 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15985 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19013 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21975 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24897 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35153 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | EMI domain | Growth factor receptor cysteine-rich domain superfamily | Laminin-type EGF domain | MEGF10/SREC1/2-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QIB9 | InterPro | 1546 | ||||||||||
| UniProtKB:A0A8M9PVQ9 | InterPro | 1503 | ||||||||||
| UniProtKB:A0A8M3B4A3 | InterPro | 1589 | ||||||||||
| UniProtKB:A0AB32TY92 | InterPro | 1454 | ||||||||||
| UniProtKB:A0AB32TZQ8 | InterPro | 1546 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
megf6b-201
(1)
|
Ensembl | 5,889 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-220D24 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-231N5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306294 (1) | 5565 nt | ||
| Genomic | GenBank:CR847970 (2) | 161576 nt | ||
| Polypeptide | UniProtKB:A0A8M3B4A3 (1) | 1589 aa |
- Comparative Orthology
- Alliance
- Teerlink, C.C., Jurynec, M.J., Hernandez, R., Stevens, J., Hughes, D.C., Brunker, C.P., Rowe, K., Grunwald, D.J., Facelli, J.C., Cannon-Albright, L.A. (2020) A role for the MEGF6 gene in predisposition to osteoporosis. Annals of human genetics. 85(2):58-72
- Hoshijima, K., Jurynec, M.J., Klatt Shaw, D., Jacobi, A.M., Behlke, M.A., Grunwald, D.J. (2019) Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Developmental Cell. 51(5):645-657.e4
- Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163
- Kossack, M.E., High, S.K., Hopton, R.E., Yan, Y.L., Postlethwait, J.H., Draper, B.W. (2018) Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Genetics. 211(1):219-233
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Westcot, S.E., Hatzold, J., Urban, M.D., Richetti, S.K., Skuster, K.J., Harm, R.M., Lopez Cervera, R., Umemoto, N., McNulty, M.S., Clark, K.J., Hammerschmidt, M., Ekker, S.C. (2015) Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS One. 10:e0130688
- Clark, K.J., Balciunas, D., Pogoda, H.M., Ding, Y., Westcot, S.E., Bedell, V.M., Greenwood, T.M., Urban, M.D., Skuster, K.J., Petzold, A.M., Ni, J., Nielsen, A.L., Patowary, A., Scaria, V., Sivasubbu, S., Xu, X., Hammerschmidt, M., and Ekker, S.C. (2011) In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nature Methods. 8(6):506-512
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