Gene
tnfrsf18
- ID
- ZDB-GENE-101104-7
- Name
- tumor necrosis factor receptor superfamily, member 18
- Symbol
- tnfrsf18 Nomenclature History
- Previous Names
-
- gitr (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable tumor necrosis factor receptor activity. Predicted to be involved in positive regulation of cell adhesion. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in gut; kidney; spleen; and thymus. Orthologous to human TNFRSF18 (TNF receptor superfamily member 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Poulton et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33941 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tnfrsf18 | N/A | Poulton et al., 2010 |
| MO2-tnfrsf18 | N/A | Poulton et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TNF receptor superfamily member 18 | TNFR/NGFR cysteine-rich region | Tumour necrosis factor receptor 18 | Tumour necrosis factor receptor 18, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A9Y5K8 | InterPro | 259 | ||||
| UniProtKB:E7F804 | InterPro | 261 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf18-201
(1)
|
Ensembl | 1,540 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20F24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113524 (1) | 896 nt | ||
| Genomic | GenBank:BX950172 (1) | 231139 nt | ||
| Polypeptide | UniProtKB:E7F804 (1) | 261 aa |
- Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wiens, G.D., and Glenney, G.W. (2011) Origin and evolution of TNF and TNF receptor superfamilies. Developmental and comparative immunology. 35(12):1324-35
- Poulton, L.D., Nolan, K.F., Anastasaki, C., Waldmann, H., and Patton, E.E. (2010) A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. The International journal of developmental biology. 54(5):815-825
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