Gene
gpam
- ID
- ZDB-GENE-101026-1
- Name
- glycerol-3-phosphate acyltransferase, mitochondrial
- Symbol
- gpam Nomenclature History
- Previous Names
-
- mtGPAT (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in glycerophospholipid metabolic process and triglyceride biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in mitochondrial outer membrane and plasma membrane. Predicted to be active in mitochondrion. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11844 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22137 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27984 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42065 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002123 | Phospholipid/glycerol acyltransferase |
| Domain | IPR041728 | GPAT/DHAPAT, acyltransferase domain |
| Domain | IPR045520 | GPAT/DHAPAT, C-terminal domain |
| Family | IPR022284 | Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase |
| Family | IPR028354 | Glycerol-3-phosphate acyltransferase, PlsB |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycerol-3-phosphate acyltransferase, PlsB | Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase | GPAT/DHAPAT, acyltransferase domain | GPAT/DHAPAT, C-terminal domain | Phospholipid/glycerol acyltransferase |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7F6M7 | InterPro | 826 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-92E20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306794 (1) | 5269 nt | ||
| Genomic | GenBank:CU462848 (1) | 92355 nt | ||
| Polypeptide | UniProtKB:E7F6M7 (1) | 826 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Her, G.M., Hsu, C.C., Hong, J.R., Lai, C.Y., Hsu, M.C., Pang, H.W., Chan, S.K., and Pai, W.Y. (2011) Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio). Biochimica et biophysica acta. Molecular and cell biology of lipids. 1811(9):536-48
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