ZFIN is now using GRCz12tu for Genomic Data
Gene
lrrk1
- ID
- ZDB-GENE-101019-2
- Name
- leucine-rich repeat kinase 1
- Symbol
- lrrk1 Nomenclature History
- Previous Names
-
- zmp:0000000961
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteosclerotic metaphyseal dysplasia | Alliance | Osteosclerotic metaphyseal dysplasia | 615198 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M9QDD6 | InterPro | 2007 |
| UniProtKB:A0AC58G340 | InterPro | 1999 |
| UniProtKB:A0AC58G342 | InterPro | 2055 |
| UniProtKB:A0AC58G346 | InterPro | 2029 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance