Gene
lrrk1
- ID
- ZDB-GENE-101019-2
- Name
- leucine-rich repeat kinase 1
- Symbol
- lrrk1 Nomenclature History
- Previous Names
-
- zmp:0000000961
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Orthologous to human LRRK1 (leucine rich repeat kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteosclerotic metaphyseal dysplasia | Alliance | Osteosclerotic metaphyseal dysplasia | 615198 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR050216 | Leucine-rich repeat domain-containing protein |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR002110 | Ankyrin repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR025875 | Leucine rich repeat 4 |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | C-terminal of Roc (COR) domain | Leucine-rich repeat | Leucine rich repeat 4 | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | P-loop containing nucleoside triphosphate hydrolase | Protein kinase-like domain superfamily | Roc domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | WD40-repeat-containing domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QDD6
|
2007 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance